生物活性：SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
QY千亿国际 has not independently confirmed the accuracy of these methods. They are for reference only.
SN-38-d3 相关抗体:
TOP2A Antibody
DXd Antibody (YA897)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
SN38 Antibody (YA923)
Topoisomerase I Antibody (YA2237)
分子量：395.42
Formula：C22H17D3N2O5
CAS 号：718612-49-8
非标记 CAS：86639-52-3
性状：固体
颜色：Off-white to light yellow
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month