生物活性：Nefopam-d4 (hydrochloride) is deuterium labeled Nefopam (hydrochloride). Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
QY千亿国际 has not independently confirmed the accuracy of these methods. They are for reference only.
Nefopam-d4 hydrochloride 相关抗体:
Beta-Catenin Antibody
TCF7L2/TCF4 Antibody
beta Catenin Antibody (YA936)
beta Catenin Antibody (YA938)
Phospho-delta 1 Catenin (Ser268) Antibody (YA1019)
Phospho-beta Catenin (Ser33/Ser37) Antibody (YA3096)
gamma Catenin Antibody
beta Catenin Antibody (YA937)
Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018)
Phospho-delta 1 Catenin (Thr916) Antibody (YA1020)
分子量：293.82
Formula：C17H16D4ClNO
CAS 号：2747915-60-0
非标记 CAS：23327-57-3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (538 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11.
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[3]. Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.
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[4]. Poon R, et al. A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. PLoS One. 2012;7(5):e37940.
 [Content Brief]